#4 The North-West Derby - Liverpool vs Manchester United
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38 League titles and 9 European Cups are shared between Liverpool and Manchester United, the two greatest clubs in England. Despite the rise and fall of other clubs around them, the North-West Derby will forever remain as the greatest fixture in English football. The only reason it ranks low on this list is that rarely have both teams had their peak at the same time.
Commercially, no club football fixture is bigger than this one - this match attracts hundreds of millions of viewers across the globe, far more than any other league game. The rivalry has been fuelled by the proximity of the two major cities that they represent, their historic economic and industrial rivalry, significant periods of domestic footballing dominance and European success, and their popularity at home and abroad.
While Bob Paisley and Bill Shankly made Liverpool the strongest club in Europe, Sir Alex Ferguson took that status to Manchester United in a 20 year period where the Reds declined. Right now, Liverpool are on the rise again and might lower the gap between them and their rivals in terms of league trophies won. Without a doubt, this game is one of the most highly-anticipated games in football.