Top 5 predictions for Villarreal vs Manchester United | UEFA Champions League 2021-22

#3 Key absentees a concern for Manchester United

Watford v Manchester United - Premier League

Injuries have only piled on the agony for Manchester United in the last few weeks. There are plenty of injury concerns with star players like Paul Pogba, Raphael Varane and Luke Shaw all being ruled out against Villarreal. Forwards Edinson Cavani and Mason Greenwood are also not in contention to start the game.

Manchester United might have a lot of firepower but it will be an uphill battle for Carrick in his first game. The Red Devils are severely depleted with key absentees in all departments - attack, midfield and defense. Moreover, the United team will be without any rest after the humiliation against Watford.

The absence of world class players like Pogba, Varane and Cavani is a huge blow to any team. It remains to be seen how Manchester United will line-up under Carrick, with several of their players out of the game.

#2 Villarreal defense to keep Cristiano Ronaldo quiet

Watford v Manchester United - Premier League

It is never wise to bet against a player like Cristiano Ronaldo. The Portuguese icon is capable of changing the dynamic of a match in the blink of an eye, as was evident against Villarreal at Old Trafford.

Ronaldo's five goals in the 2021-22 Champions League have been crucial for Manchester United, helping them stay at the top of their group.

However, Ronaldo is not getting any younger and he has endured some quiet nights since arriving in Manchester this summer. Villarreal will consider themselves unlucky as they performed well to keep the 36-year old quiet for the majority of their encounter at Old Trafford.

Our guess is that Villarreal will be extra cautious with Ronaldo and will likely keep him from scoring against them.

#1 Manchester United will fail to win the game

Watford v Manchester United - Premier League

Solskjaer had faults of his own but the continued lackluster performances from Manchester United players remains a major concern. With Carrick taking over as interim manager, it will be up to the players to respond positively against Villarreal.

Both teams will be looking to seal a berth in the knockout stages and a win will definitely be a crucial factor. Unai Emery's men were unfortunate at Old Trafford and will have revenge on their minds in the reverse fixture. At their own home, the advantage will be with the La Liga team.

On paper, Manchester United have enough firepower to outmuscle Villarreal. However, considering their recent form, even a draw will be sufficient for the time being. Our guess is that they will fail to win the tie and probably even lose to Villarreal to prolong their misery.