#4 The centre-back partnership of Spurs
Toby Alderweireld is the automatic choice to start in center back spot. There are options to partner him. A three-man defense seems extremely hypothetical and thus a 2 man defense it is. But since Davinson Sanchez has a minor injury, he would miss the game. Pochettino usually doesn't like to throw his players returning from injury right into the fire. But Jan Vertonghen seems a hot favorite to start.
Simply because the other options available are too dangerous to gamble with against Chelsea. Dier starting at center-back and facing Morata, Willian and Hazard, is as bad as it is. Juan Foyth is another option but he could also be a bad gamble to take.
The midfield options are also not very promising for Spurs. The prospect of Dier and Winks against Kante and Barkley is not at all a good one for Spurs. We will find the answer on Saturday night.