#4 Most of Barcelona's attackers are struggling
Some of the best forwards in the world currently ply their trade at Barcelona as Messi has an able supporting cast including the likes of Philippe Coutinho, Luis Suarez and Ousmane Dembele, who are all quality players in their own rights and are more than capable of harming Manchester United.
However, none of them is exactly in awe-inspiring form at the moment. Suarez might have scored 20 goals in the league but he is yet to get off the mark in seven games in the continental competition this season, while he has gone over three years without an away goal in the Champions League.
Dembele has shown flashes of brilliance but his persistent fitness concerns mean that the World Cup winner cannot exactly be relied upon, while summer arrival Malcom is yet to fully win the trust of manager Ernesto Valverde.
Nevertheless, Coutinho is unarguably the worst hit as the Brazilian has horribly struggled for form this season, scoring just 10 goals in 44 matches all season, while also failing to nail down a regular spot with speculations suggesting that he is discontent at the club and is seeking a transfer just a year on from his record-breaking arrival.
Goals win matches and Barcelona would need them if they are to eliminate Manchester United. However, given the struggles of their forwards, this could prove problematic, especially considering Messi's poor record at this stage.