With the Liverpool derby coming in the weekend, and Manchester United having been already qualified into the knockout stages of the Champions League, Jose Mourinho is expected to ring changes in the side.
Manchester United sits second in Group H, and can take the first position only if Juventus lose their match against Young Boys, and the Red Devils beat Valencia in Spain.
Valencia, on the other hand, are already out of the competition but have confirmed the third place in the group, which paves way for their entry into the Europa League.
The match will be highlighted by the return of Paul Pogba to the starting line-up after being benched in the last 2 matches for Manchester United due to reports of a bust-up with the coach.
Another forgotten man, Andreas Pereira, is also confirmed to feature against the club where he spent last season on loan.
Valencia vs Manchester United: Kick-off information
Date: 12 December 2018
Time: 21:00 (local time), 01:30 (IST)
Venue: Mestalla, Valencia
Livestream: SonyLiv
Valencia vs Manchester United: Team news
Valencia is likely to be without Gabriel Paulista, Kevin Gameiro, and Jeison Murillo, with the trio missing out with injuries, while fullback Jose Gaya is also out with a suspension.
Jose Mourinho will be once again without a host of players. Anthony Martial, Luke Shaw, and Chris Smalling join the injury list along with long time absentees Victor Lindelof and Alexis Sanchez.
Paul Pogba, Sergio Romero, and Andreas Pereira are confirmed starters for Manchester United, while Eric Baily is expected to come in for the injured Smalling. Academy players Mason Greenwood and James Garner may make their competitive debut for the club after being called up to the first team squad.
Valencia vs Manchester United: Probable line-up
Valencia: Neto, Wass, Garay, Diakhaby, Lato, Soler, Parejo, Kondogbia, Guedes, Mina, Batshuayi
Manchester United: Romero, Darmian, Jones, Bailly, Dalot, Fred, Pogba, Pereira, Rashford, Lukaku, Mata
Valencia vs Manchester United: Form guide
The last 5 competitive matches
Valencia: D-W-L-L-W
Manchester United: W-D-D-W-D
Valencia vs Manchester United: Head to head
Valencia: 1 win
Manchester United: 2 wins
Draw: 6 draw
Valencia vs Manchester United: Prediction
With both teams likely to ring in a couple of changes, the match is expected to be a rather dull affair.
Prediction: Valencia 1-1 Manchester United