#1 Anderson Silva vs. Chris Weidman
Anderson Silva, who has often been considered to be the best pound for pound fighter in the world, suffered a career-threatening injury when he faced Chris Weidman in a rematch at UFC 168. Chris Weidman won the first fight by knocking out a cocky Silva to become the Middleweight Champion in the process.
In the second fight, Anderson was quite aggressive following his earlier loss and was troubling the All-American with his leg kicks. On one such occasion, Anderson went for a hard left low kick which Weidman checked. What happened next is still one of the most heartbreaking moments in UFC history.
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The impact led to Silva breaking his shin bone. Anderson crumpled on the floor due to intense pain and Weidman was awarded the winner by TKO. 'The Spider' has sadly not been the same ever since.