#2. Anthony Pettis vs. Clay Collard II - PFL lightweight division
This would be another PFL rematch as the pair met last year in the opening week of the season. On that occasion, Clay Collard spoiled Anthony Pettis' promotional debut when he pulled off the upset in a highly entertaining fight. With both men starting the 2022 season strongly, a second bout could be a big deal.
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Collard is an entertaining and talented fighter who made it all the way to the semi-finals of the 2021 season. He's fought the likes of Max Holloway in the UFC and so isn't intimidated when facing big names like Pettis. As mentioned previously, Pettis remains a big star in the sport despite being towards the end of his career.
Given how exciting the first fight between the two was, there would already be significant demand for the rematch. Add in the fact that both men are currently on course to make the playoffs this season, the increased stakes could make this a big-time matchup.
#1. Kayla Harrison vs. Cris Cyborg - PFL women's lightweight division
Kayla Harrison is the face of the promotion. While it was widely speculated that she might fight elsewhere during her window of free agency, she is now back and once again competing in the 2022 season. Unfortunately, there simply aren't too many exciting matchups for her at the moment.
The most intriguing fight for her in the promotion is likely Julia Budd. That fight, however, lost a lot of steam when Budd lost her opening fight for the promotion. That fight doesn't come close to how big a potential bout between Kayla Harrison and Cris Cyborg would be.
Two of the greatest competitors in women's MMA history clashing would be a massive deal. While Cyborg is currently signed to Bellator, her contract is expiring soon and it seems like an agreement could be reached. If that does indeed happen, it would be the biggest fight in the history of the PFL.