#5 Vitor Belfort
Since his debut in 1996, Vitor Belfort has been one of the pioneers of mixed martial arts and one of the leading men in the UFC. This was especially true in 2013 when Belfort absolutely mauled Michael Bisping, Luke Rockhold, and Dan Henderson all in the same year to go on a run for the ages.
The problem arose shortly after that, though, as the Nevada State Athletic Commission took the decision to make Testosterone Replacement Therapy illegal – something Belfort was known to use. The results after this decision were there for all to see.
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As you can see from the image above, Belfort lost an incredible amount of muscle and hasn’t hit the heights he did in his TRT days, losing three out his next four fights.