#2 Anderson Silva
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From 2006 to 2013, Anderson Silva's name was synonymous with several things: "Phenom", "Human Highlight Reel", and even the "Greatest of All-Time." Four years later, he was suddenly a product of two failed drug tests in the UFC.
"The Spider" was first suspended in 2015 after he tested positive for androstane, an anabolic steroid, and warranted him a yearlong suspension. The same thing happened during his pre-fight drug test for UFC Shanghai last November when he tested positive for a still undetermined substance, causing him to be pulled out of his scheduled headliner against Kelvin Gastelum.
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Nowadays, Silva is no longer in the "Greatest of All-Time" conversation among many fans, mainly because of his failed drug tests. While he did cry foul on both instances, saying he was a victim of tainted supplements, it is indeed disappointing to see one of the most notable fighters in history fall from grace this hard.