#3 Uncertainty in length of career
Entering an Octagon is not the best way for a person to ensure that they have a long healthy life.
In fact, an Octagon is a place where a person is battered continuously by their opponent who is intent on beating them up physically.
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The same can be said for WWE, as in WWE the body of the Superstars takes a lot of punishment. They have to drop off high heights and perform bumps which no untrained person should ever attempt for any reason. However, when they are in the ring, they are working with their opponents, and the spots are measured to be safe with all precautions taken.
In an Octagon, however, after just a few fights, one blow can be the difference between life and death -- something which has been seen outside UFC, where professionals have even died during a fight.