5 times the UFC had to replace a main event on late notice

#4. UFC 215 - Amanda Nunes vs. Valentina Shevchenko 2

This event was the promotion's first event to be held in Edmonton, Canada and was originally set to be headlined by a flyweight title fight. Demetrious Johnson was scheduled to defend his 125 lb title against Ray Borg, who was 5-1 in his last six fights.

Unfortunately, Borg would be forced to withdraw from the fight mere days before the event was to take place. 'The Tazmexican Devil' came down with an illness that resulted in doctors deeming him medically unfit to compete.

Instead, a women's bantamweight title fight would be moved to the headline bout. A rematch between two of the all-time greatest women's MMA fighters took place in the form of Amanda Nunes vs. Valentina Shevchenko 2.

Nunes ultimately won a very close match in a split-decision victory, cementing her place as the best female fighter in the promotion at the time. Not all fans were happy with the result, and many have called for a trilogy bout to be made in the future.

Amanda Nunes vs. Valentina Shevchenko 2 Weigh-ins

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#3. UFC 206 - Max Holloway vs. Anthony Pettis

UFC 206 was initially scheduled to feature a main event rematch between Daniel Cormier and Anthony Johnson. After several canceled bouts with Jon Jones, Cormier was looking for a new opponent, and Johnson had won three consecutive fights since their first matchup.

However, as fight day approached, news broke that Cormier had suffered a torn adductor in his groin. Thankfully, the promotion had an electric co-main event that was moved to the main-event slot.

Max Holloway took on Anthony Pettis in an interim featherweight title bout. This would be Holloway's breakout fight, as he TKO'd the former lightweight champion, beginning one of the all-time great runs at 145lbs. Pettis would move back up to lightweight, and then welterweight, eventually parting ways with the promotion in 2020.

Max Holloway vs. Anthony Pettis