#4 Junior Dos Santos
Well, no surprises here. Junior Dos Santos is indeed one of the toughest fighters not only in the sport of Mixed Martial Arts, but in all of combat sports. The man known as "Cigano" started off as a BJJ fighter, and eventually took to the art of boxing -- The rest, as they say, is history.
JDS absolutely destroyed everyone who stood in front of him, during his ascent to the UFC Heavyweight throne. He notably became the first man to KO one of the most well-rounded Heavyweights of all time -- Cain Velasquez -- in their first encounter back in 2011.
Unfortunately, Dos Santos subsequently suffered a pair of devastating losses to the aforementioned Velasquez, at UFC 155 and UFC 166 respectively -- enduring a prolonged beating in both fights which lasted almost 10 rounds in total.
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Nevertheless, Dos Santos still fights on in his bid to regain the UFC Heavyweight Title, and is well known for never letting losses hurt his confidence -- adhering to the principle of never giving up, much like his idol, the fictional movie character "Rocky Balboa"...