UFC Fight Night: Cannonier vs. Gastelum is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 21, 2021 at the UFC Apex Facility in Nevada, Las Vegas Metropolitan Area, United States.
Main Card
| Weight Class | Fight Card | Method | Round | Results |
| Middleweight | Jared Cannonier vs. Kelvin Gastelum | Decision | R5 (05:00) | Jared Cannonier def. Kelvin Gastelum |
| Lightweight | Clay Guida vs. Mark Madsen | Decision | R3 (05:00) | Mark Madsen def. Clay Guida |
| Heavyweight | Parker Porter vs. Chase Sherman | Decision | R3 (05:00) | Parker Porter def. Chase Sherman |
| Bantamweight | Trevin Jones vs. Saidyokub Kakhramonov | Submission | R3 (04:39) | Saidyokub Kakhramonov def. Trevin Jones |
| Lightweight | Vinc Pichel vs. Austin Hubbard | Decision | R3 (05:00) | Vinc Pichel def. Austin Hubbard |
| Flyweight | Alexandre Pantoja vs. Brandon Royval | Submission | R2 (01:46) | Alexandre Pantoja def. Brandon Royval |
Preliminary Card
| Weight Class | Fight Card | Method | Round | Results |
| Featherweight | Austin Lingo vs. Luis Saldana | Decision | R3 (05:00) | Austin Lingo def. Luis Saldana |
| Bantamweight | Brian Kelleher vs. Domingo Pilarte | Decision | R3 (05:00) | Brian Kelleher def. Domingo Pilarte |
| Women Bantamweight | Bea Malecki vs. Josiane Nunes | KO/TKO | R1 (04:54) | Josiane Nunes def. Bea Malecki |
| Light Heavyweight | William Knight vs. Fabio Cherant | KO/TKO | R1 (03:58) | William Knight def. Fabio Cherant |
| Lightweight | Roosevelt Roberts vs. Ignacio Bahamondes | KO/TKO | R3 (04:55) | Ignacio Bahamondes def. Roosevelt Roberts |
| Welterweight | Sasha Palatnikov vs. Ramiz Brahimaj | Submission | R1 (02:33) | Ramiz Brahimaj def. Sasha Palatnikov |
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