#4 Frank Mir
Frank Mir was on top of the world. He was only 25 years old, 8-1 and just crowned the UFC Heavyweight champion after breaking Tim Sylvia's arm.
Then disaster struck...
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Mir had gotten into a bad motorcycle accident which resulted in him breaking his femur in two places and tearing all the ligaments in his knee. He was stripped of the title and wasn't expected to return to the ring.
But what do you know, Mir would return and solidify himself as one of the all-time greats at Heavyweight as he would have twenty of his twenty-nine career bouts take place after his accident. One of which including an interim title winning effort over a fellow legend, Antonio Rodrigo "Minotauro" Nogueira as well as three separate title shots.
It's crazy in hindsight that Mir wasn't expected to fight ever again and then see all of the amazing moments he provided us within the thirteen years that followed his accident. How much the injury may have affected his career trajectory, we'll never know. But it's safe to say he made up for it pretty well with a lasting legacy and it was one hell of a return for the Las Vegas-born UFC original.