Yes, Missy Cooper (Raegan Revord) is in The Big Bang Theory. Missy is undoubtedly the most eccentric member of Cooper's family, at least in Young Sheldon, but in The Big Bang Theory, her character changes significantly.
The first member of Sheldon's family to feature in the original series is his sister, who debuted in "The Porkchop Indertiminacy," season 1, episode 15. Since then, she has made intermittent appearances across the 12 seasons of the show, and her narrative is continued in the Young Sheldon spin-off prequel.
Sheldon Cooper's fraternal younger twin sister is Melissa "Missy" Cooper. Her personality is completely different from her brother's. She has a very cheeky sense of humour, is charming and friendly, and is not above engaging in physical altercations.
Missy’s presence in The Big Bang Theory
Missy first appears in S01 in “The Porkchop Indeterminacy”. Sheldon's sibling Missy on the show is essentially nonexistent, as she and her brother don't go along well. Sheldon is more interested in which of his buddies she would date than caring about her life, and she seldom visits her brother.
CBS uses Young Sheldon to defend Missy's terrible outcome on The Big Bang Theory. The show ran for many years, during which time Sheldon's (Jim Parsons) family made appearances.
Among them was his twin sister Missy, whom Leonard (Johnny Galecki) and the other friends are shocked to discover that she wasn't at all like their socially awkward genius friend. But irrespective of being smart, Missy is the least successful Cooper sibling.
Missy just has two appearances on The Big Bang Theory. After season 1, she wouldn't return until 10 years later to attend Sheldon and Amy's (Mayim Bialik) wedding.
She's mentioned more than once in between her cameos, but even with her limited role in the sitcom centred around nerds, she leaves an impression on the audience.
As it didn't seem like Sheldon and Missy were close in the prequel series, Missy isn't seen in as many episodes of The Big Bang Theory as Mary has. Mary, though, would typically go after and pamper Sheldon.
Eventually, Missy from The Big Bang Theory marries and has children. She's occupied with this for the remainder of the year, which makes it challenging for her to see her brother in California.
Missy's life following The Big Bang Theory has not been extensively discussed, but the show established that she was the least fulfilled of the three Cooper siblings in terms of personal and professional life.
Missy endured a terrible marriage, while Georgie established Mr. Tyre and Sheldon strived to become a Nobel Prize-winning physicist. Her most recent employment was as a hostess at Fuddruckers. While she didn't appear to mind, she could have secured a more satisfying position, given her potential, which Young Sheldon amply demonstrated.
Missy lacks the wit or sophistication of Georgie or Sheldon but is charming, has a high EQ and is street-smart. If she had learned to put more effort into being herself rather than trying hard to be someone else, she might have succeeded in her chosen path.
Missy has a difficult trajectory ahead of her in Young Sheldon, even if her life hasn't been as eventful as Georgie's or Sheldon's. She's the closest of the three Cooper children to Georgie, who according to The Big Bang Theory is only a few years away from dying.