Hashirama Senju and Madara Uchiha
Hashirama Senju and Madara Uchiha, despite their quarrels, united all the clans in one village and called it Konoha. Butsuma Senju’s son, Hashirama Senju married Mito Uzumaki. Hashirama was the first Hokage of the village.
Following Hashirama’s footsteps, his hot-blooded younger brother Tobirama became the second Hokage of the Konoha village. Another notable descendant of the Uzumaki clan was Kushina Uzumaki.
Tajima Uchiha was a descendant of Indra Otsutsuki. Tajima Uchiha gave birth to Madara Uchiha who was the leader of the Uchiha clan. Further descendants of the Uchiha clan were Fugaku Uchiha and Mikoto Uchiha. Fugaku and Mikoto Uchiha gave birth to two sons who are possibly the most popular characters in the show. They are Itachi Uchiha and Sasuke Uchiha.
Kushina Uzumaki and Minato Namikaze
Kushina Uzumaki, of the Uzumaki clan, was the second Jinchuriki of the nine-tailed beast. She inherited the nine tail from Mito Uzumaki. Kushina was a great asset to the Uzumaki clan due to her Chakra and the tailed beast that was sealed within her.
She married Minato Namikaze, who was known as the Yellow Flash of Konoha Village. He developed the Rasengan technique and was the fourth Hokage of the Konoha village. Kushina married Minato and gave birth to none other than Naruto Uzumaki.
Sasuke Uchiha and Sakura Haruno
Sasuke Uchiha was the son of Fugaku and Mikoto Uchiha. He was in Team 7 which was mentored by Kakshi Hatake. His teammates were Naruto Uzumaki and Sakura Haruno. Sasuke marries Sakura Haruno, who then gives birth to Sarada Uchiha.
Naruto Uzumaki and Hinata Hyuga
Naruto Uzumaki is Minato Namikaze and Kushina Uzumaki’s son. He is the main character of the show whose strong will power and unwavering mental toughness have earned the fans’ love. His ability to push forward despite the constant struggles makes him one of the most likable characters in the show.
He married Hinata Hyuga of the Hyuga clan and gave birth to two children, Boruto and Himawari Uzumaki.