#4 Miss Jackie - WWE Cruiserweight Championship
Back in 2004, the women's evolution was a ways off yet, but WWE made a surprising move for one of their longest-tenured women stars.
Miss Jackie had wrestled extensively on the indie circuit as Miss Texas, particularly in the South West. She was brought in to WWE during the Attitude Era and functioned in a variety of roles, usually as a manager but also competing in the women's division.
Jackie was one of the most skilled females on their roster at the time, and the company decided to take advantage of that. During Chavo Guerrero's open challenge days, Jackie would answer and unseat the overconfident champion.
To be fair, the interference of Chavo Classic - that would be Chavo Guerrero Sr, Chavo Jr.'s real-life father - had as much to do with it as anything else.
Though Jackie would quickly drop the belt back to Chavo, it remains one of the more unpredictable and wild moments in WWE history.