Best DFS Picks for Los Angeles Rams vs. San Francisco 49ers- October 30 | 2022 NFL Regular Season

The San Francisco 49ers travel to Los Angeles to take on the defending Super Bowl champion Rams. The 49ers head coach Mike Shanahan has had the Rams' number. The 49ers enter this game in a transition as they will be without WR Deebo Samuel. The 49ers continue to work RB Christian McCaffrey into their offense more often.

The Los Angeles Rams are in a similar transition as they are still seeking a trade for RB Cam Akers as he sits out. The Rams are also interested in bringing some offensive firepower in at the WR position, namely, Brandin Cooks.

Today, let's look at the best DFS plays from this intriguing match-up.

Best quarterback picks

Cash Games and Tournament: Jimmy Garoppolo, QB, San Francisco 49ers (DraftKings $5.6K, FanDuel $7.1K)

I have a difficult time trusting QB Matthew Stafford. We keep reiterating that the San Francisco 49ers traditionally have dominated the Rams, but until the Rams prove us wrong, we will keep hammering home the point. Jimmy G has been excellent in the last two starts. Even without Deebo Samuel, Jimmy G has plenty of weapons to lean on.

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Best running back picks

Cash Games: Christian McCaffrey, RB, San Francisco 49ers (DraftKings $8.7K, FanDuel $8.5K)

Last week the 49ers mixed Christian McCaffrey in the offense. This week, wheels up for C-Mac. The 49ers didn't deal with several picks NOT to use the versatile back. Christian McCaffrey should touch the ball 20+ times in this one.

Tournament: Darrell Henderson Jr., RB, Los Angeles Rams (DraftKings $5.5K, FanDuel $6.5K)

With Cam Akers inactive, Darrell Henderson Jr. should have ample opportunities. DFS managers will be reluctant, given the Rams' offensive line's struggles against a dominant 49ers' defensive front. Darrell Henderson Jr. is an addition to your DFS lineup if you want to gain leverage on the field.

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Wide receivers and tight ends

Cash game: Cooper Kupp, WR, Los Angeles Rams (DraftKings $9.6K, FanDuel $9.3K)

You can expect three things in life -- death, taxes, and Cooper Kupp putting on a show every Sunday. Cooper Kupp is one of the most dominant forces we have seen in recent memory. With the way the Rams scheme Kupp open in their offense, he is a no-brainer.

Tournament: Brandon Aiyuk, WR, San Francisco 49ers (DraftKings $6.1K, FanDuel $6.7K)

With Deebo Samuel out, Brandon Aiyuk should receive plenty of work in this one. The Rams have been one of the worst defenses in the league against the pass. Look for Brandon Aiyuk to have a big afternoon.

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