Clemson vs. Louisville Prediction, Odds, Lines, Spread, and Picks- November 12 | 2022 NCAA Football Season

The Clemson Tigers return home following an embarrassing beatdown at the hands of the Notre Dame Fighting Irish to face off against the surging Louisville Cardinals, winners of four straight. The Clemson Tigers' deficiencies on offense were exploited last week -- were the Cardinals paying attention? Malik Cunningham poses a unique problem for the Clemson Tigers' defense to handle. Can the Cardinals continue their momentum to a fifth straight victory? Or will the Tigers rebound and respond at home?

The betting odds and predictions are below:

TEAMS	LINE	TOTAL
Louisville Cardinals	+7 (-110)	O 51.5 (-115)
Clemson Tigers	-7 (-110)	U 51.5 (-105)

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We have to discuss the Clemson Tigers' QB situation and D.J. Uiagalelei. The Clemson signal-caller was dreadful last weekend. A change in the QB position may not only be called for, it may be necessary.

The Clemson offense will go as far as RB Will Shipley can carry it. The multi-faceted Shipley is used as a runner and a receiver out of the backfield, as he totaled just under 1,000 yards on the season. Expect the Tigers to lean heavily on the back of their workhorse.

Malik Cunningham is a one-man show for the Cardinals as he leads the team in passing and rushing. Cunningham is spectacular in the open field with 540 rushing yards and 11 touchdowns.

Tyler Hudson has been the go-to receiver for the Tigers all season. When in doubt, Cunningham looks Hudson's way.

Clemson Tigers vs. Louisville Cardinals Game Details

Fixture: Louisville Cardinals @ Clemson Tigers

Date and Time: Saturday, November 12, 3:30 PM ET

Venue: Memorial Stadium, Clemson, South Carolina

Clemson Tigers vs. Louisville Cardinals Best Pick

The Clemson Tigers' defense will be ready for this one. The defensive front will put pressure on Malik Cunningham all afternoon. While that is traditionally a good thing, it will force Cunningham to scramble as a runner out of the pocket. Cunningham may find more success with his legs than his arm on Saturday. Take the Over on a reasonable prop bet for his rushing total.

Malik Cunningham, Rushing Yards, Over

Clemson Tigers vs. Louisville Cardinals Final Prediction

This prediction has more to do with the Tigers than it does with the Cardinals. The Clemson offense has not been up to snuff for some time, and many College Football fans saw this coming from a mile away. With a lackluster Clemson passing game, the Cardinals can stack the box to take away the run. Malik Cunningham can work his magic, and although the Tigers may escape with a victory, the Cardinals will keep this one razor-sharp.

Louisville Cardinals +7 (-110)

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