Ohio State vs. Indiana Prediction, Odds, Lines, Spread, and Picks- November 12 | 2022 NCAA Football Season

The Ohio State Buckeyes are building up to an end-of-season clash against their undefeated arch-rival Michigan Wolverines. However, they would be well advised not to get ahead of themselves. The Buckeyes, currently on a 9-0 winning streak, will have to defeat the Indiana Hoosiers this week before they turn their attention towards Michigan. Ohio State are a massive 40-point favorite. This one could be sealed at halftime.

The betting odds and predictions are below:

TEAMS	LINE	TOTAL
Indiana Hoosiers	+40 (-110)	O 58.5 (-110)
Ohio State Buckeyes	-40 (-110)	U 58.5 (-110)

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Heisman Trophy contender C.J. Stroud leads the Ohio State Buckeyes. Stroud has dominated the Big Ten with 29 TD passes to four interceptions. While Stroud has been supremely effective, it can be argued that he has missed some of his firepower of late.

Jaxon Smith-Njigba is back and is as close to 100% as he has been all season long. Having a fit and firing JSN back for the Buckeyes offense is a nightmare for any opposition.

The Buckeyes do not lack an explosive array of weapons on the outside. Marvin Harrison Jr. continues his development as a superstar with over 800 yards receiving and ten touchdowns already this season.

Emeka Egbuka provides yet another high-end receiving option for C.J. Stroud. Egbuka has just under 800 yards receiving and seven touchdowns. Imagine this trio of receivers playing in top gear, on the field at the same time!

Not to mention that the Buckeyes can run the ball as well as anyone in the Big Ten. The combination of TreVeyon Henderson and Miyan Williams causes problems aplenty for defenses. The dynamic duo in the backfield have combined for 1,200 rushing yards and 18 rushing scores.

Ohio State Buckeyes vs. Indiana Hoosiers Game Details

Fixture: Indiana Hoosiers @ Ohio State Buckeyes

Date and Time: Saturday, November 12, 12:00 PM ET

Venue: Ohio Stadium, Columbus, Ohio

Ohio State Buckeyes vs. Indiana Hoosiers Best Pick:

The Ohio State Buckeyes should take an early lead and are likely to lean on their ground game in the 2nd half to wear down the Hoosiers' defense. The Buckeyes have an outstanding offensive line that opens up wide holes for Henderson to exploit. Don't forget to take the Over.

TreVeyon Henderson, Rushing Yards: Over

Ohio State Buckeyes vs. Indiana Hoosiers Final Prediction

This one could get one-sided quickly. Ohio State have an embarrassment of riches in their ranks.While Indiana is overmatched in this one, 40 points is still a ridiculous spread. Final word : Ohio State wins by three scores, but Indiana covers.

Indiana Hoosiers +40 (-110)

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