Best NFL DFS Picks for Sunday: Buccaneers vs. 49ers- December 11 | 2022 NFL Regular Season

Tampa Bay Buccaneers travel to the West Coast to take on San Francisco 49ers. The Buccaneers will look to put distance between themselves and their AFC South rivals to win the division. The 49ers are down to their 3rd string QB and will look to keep the rest of the team functioning.

Best quarterback picks

Cash Games: Tom Brady, QB, Tampa Bay Buccaneers (DraftKings $5.6, FanDuel $7.1K)

Tom Brady and the Buccaneers offense may have finally found something during their 4th Quarter comeback on Monday Night Football.

Tournaments: Brock Purdy, QB, San Francisco 49ers (Draftkings $5.1, FanDuel $6.5K)

Do you want to go nuts? Play the rookie signal-caller against Tampa Bay, an area where most DFS players are scared to death.

$1,000 No Sweat First Bet with FanDuel

Best running back picks

Cash Games: Christian McCaffrey, RB, San Francisco 49ers (DraftKings $8.5, FanDuel $8.5K)

The Buccaneers defense is stout up front, but Christian McCaffrey can cause serious damage as a pass-catcher out of the backfield. Look for the rookie QB to lean on C-Mac as much as anyone in the 49ers' offense.

Tournament: Rachaad White, RB, Tampa Bay Buccaneers (DraftKings $5.5K, FanDuel $6.8K)

The 49ers' defense has beaten up the opposition lately, so the match-up isn't great. Rachaad White remains in a great position as Leonard Fournette is questionable at best for this one.

Wide receivers and tight ends

Cash Games: Chris Godwin, WR, Tampa Bay Buccaneers (DraftKings $6.7K, FanDuel $7.5K)

Chris Godwin continues to improve every week as he gets more and more comfortable following his injury. Godwin has become central to the success of the Buccaneers' offense. Tom Brady needs someone who can work the slot position and the intermediate area, and that player is Godwin. Look for the 49ers' defense to target Mike Evans and attempt to take him out of the game, allowing more targets to go the way of Chris Godwin.

Tournament: Deebo Samuel, WR, San Francisco 49ers (DraftKings $6.1K, FanDuel $7.1K)

It's tough to say as to what the San Francisco 49ers offense will look like on Sunday under 3rd string QB Brock Purdy. The rookie signal-caller was rushed into action on Sunday when Jimmy Garoppolo went down with an ankle injury. Purdy looked the part and kept the 49ers' offense on course. If there is any team that has the weapons to insulate the QB play, it is the 49ers. Look for Purdy to target the receivers and playmakers, letting them use their athleticism to make defenders miss in the open field. Our best guess is that Brock Purdy under center is a bump up for Christian McCaffrey and Deebo Samuel and a bump down for George Kittle and Brandon Aiyuk.

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