Kansas City Chiefs vs. San Francisco 49ers odds, lines, picks, and prediction - October 22 | 2022 NFL Week 7

On Sunday, the Kansas City Chiefs (4-2) will travel across the country to take on the San Francisco 49ers (3-3). The 49ers' top-ranked defense was gashed last Sunday, allowing Atlanta Falcons QB Marcus Mariota to toss a pair of scores and run one in a 28-14 road loss.

Veteran QB Jimmy Garoppolo turned the ball over three times, including a fumble return for a Falcons touchdown. Meanwhile, last weekend, the Chiefs lost in a playoff rematch against the Buffalo Bills. The Bills took a 24-20 lead with 1:04 allowing Chiefs QB Patrick Mahomes to go the length of the field for a potential game-winning drive.

However, Mahomes misfired on the first play before Buffalo CB Taron Johnson iced the game with a clutch interception of the former MVP. The Chiefs have won four of the last five against San Fran, including a win in Super Bowl 54.

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Kansas City Chiefs vs. San Francisco 49ers Betting Odds

Team	Spread	Over/Under	Moneyline
KC Chiefs	-1.5	o48.5	-134
SF 49ers	+1.5	u48.5	+114

All Lines Provided by FanDuel Sportsbook

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Tale of the Tape

The Kansas City Chiefs remain one of the most well-run organizations with head coach Andy Reid at the helm. QB Patrick Mahomes remains one of the best in the business, throwing for 17 touchdowns to four picks in six games. Kansas City ranks in the top five within the NFL in total yards, passing yards, points, and third-down conversions. TE Travis Kelce remains a matchup nightmare for opposing defenses.

The All-Pro is averaging 75.8 receiving yards a game while leading the NFL with seven receiving touchdowns. The Chiefs will also look to keep WR JuJu Smith-Schuster going. The offseason acquisition had five catches for 113 yards and his first TD reception in the loss against Buffalo.

The Chiefs' defense, led by DL Chris Jones, is one of the best against the run. Kansas City ranks in the top six in all significant defensive stats against the run, including yards allowed per attempt (4.1) and yards allowed (543 through six games). However, the secondary has had issues with high-powered passing attacks, highlighted by Bills QB Josh Allen throwing for 329 passing yards and three touchdowns last weekend.

The San Francisco 49ers offense will need to bounce back significantly to hang with a juggernaut like the Chiefs. It starts with QB Jimmy G's play. The 49ers' signal-caller needs to protect the football and avoid turnovers. The rushing attack has been mediocre compared to Kyle Shanahan's past offenses, but they just received a massive boost through a trade with the Carolina Panthers.

On Thursday, the 49ers sent four draft picks to the Panthers in exchange for star running back Christian McCaffrey. McCaffrey is one of the game's best backs, primarily due to his skill set. In 2019, the 26-year-old became one of just three players in NFL history to surpass 1,000 rushing yards and 1,000 receiving yards in the same season.

Despite the injuries suffered in the beginning of the season, the San Francisco defense remains elite. The front seven is the best in the NFL in rushing yards allowed per attempt at 3.1. The secondary ranks in the top five in the NFL in net yards per attempt (4.9) and passing touchdowns allowed (4).

Defensive coordinator DeMeco Ryan will welcome DE Nick Bosa and S Jimmie Ward back with open arms. Both standouts practiced fully and were absent from the injury report heading into Week 7.

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Kansas City Chiefs vs. San Francisco 49ers Betting Prediction

San Fran got a mega star in Christian McCaffrey, while reinforcements are on their way via the injury list. The usually overly careful Jimmy G should rebound nicely in a stadium where he has tossed 40 touchdowns to 17 interceptions in his career. Meanwhile, the Chiefs' run game could quickly become nonexistent. All it takes is the 49ers to win the turnover battle to play into the San Francisco style of play.

Prediction: 49ers +1.5 (+114)

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