Clemson Tigers vs. Notre Dame Fighting Irish Odds, Lines, Prediction, and Picks- November 5 | 2022 NCAA Regular Season

Can the Clemson Tigers remain unbeaten over a hostile Notre Dame?
Can the Clemson Tigers remain unbeaten over a hostile Notre Dame?

The undefeated Clemson Tigers continue to survive somehow, someway. The Tigers were up against it last week against Syracuse, but they fought back to remain unbeaten.

Notre Dame has fought back in its own right. The Irish dropped the first two games of the season but have battled back to win five of their last six. The Notre Dame crowd will be hype for this one. Can the Tigers survive another tall task?

The betting odds and predictions are below:

The Notre Dame Fighting Irish are led by the gutsy QB play of Drew Pyne. Pyne has stepped into the starting role and has been efficient with 13 TD to 4 interceptions.

Michael Mayer has been a match-up problem for defenses as he is too big for defensive backs and too quick for linebackers. Mayer has the looks of a future 1st round pick.

The Irish running game is keeping their offense ahead of the chains. Notre Dame utilizes a three-headed approach in the backfield, anchored by Audric Estime, Logan Diggs, and Chris Tyree.

Can DJ Uiagalelei hold on to the starting QB job? Uiagalelei has looked shaky in spots this season, and his inconsistencies at the position could be costly for the Clemson Tigers' title hopes.

Will Shipley has been as dynamic as advertised. The versatile back is averaging six yards per carry and has carried the Clemson offense at times this season.

Clemson Tigers vs. Notre Dame Fighting Irish Game Details

Fixture: Clemson Tigers @ Notre Dame Fighting Irish

Date and Time: Saturday, November 5, 7:30 PM ET

Venue: Notre Dame Stadium, Notre Dame, Indiana


Clemson Tigers vs. Notre Dame Fighting Irish Best Pick:

The Clemson Tigers' passing game isn't scaring anyone. The QB play has been erratic, and the Tigers don't have the dominant pass-catchers they have had in years past.

Will Shipley is the engine of the Clemson Tigers' offense now. Expect Dabo and company to lean on the run game in a hostile environment.

Will Shipley, 84.5 Rushing Yards: Over


Clemson Tigers vs. Notre Dame Fighting Irish Final Prediction

Notre Dame has been impressive in how they have rallied during what could have been a lost season. The Irish have enough on defense to give Clemson trouble. The Tigers' running game remains the 'X' factor and will propel them to victory.

Clemson Tigers: -3.5 (-110)

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Edited by Mudeet Arora
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