Best Parlay (+409) for Chargers vs Cardinals - Week 12 - November 27 | 2022 NFL Football Season

The Arizona Cardinals (4-7) will host the Los Angeles Chargers (5-5) on Sunday.

Last week, the Cardinals were blown out by their division foe, the San Francisco 49ers, 38-10. Quarterback Kyler Murray didn't play due to injury but expects to be under center this week against LA. Meanwhile, the Chargers lost a heartbreaker to the Chiefs 30-27. LA scored to take the lead with under two minutes to go but let up a third Patrick Mahomes to Travis Kelce touchdown with 37 seconds remaining.

Below, we'll go through the best parlay to make for Sunday's contest.

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NFL Parlay Leg #1: Los Angeles Chargers RB Austin Ekeler Any Time Touchdown Scorer (-210)

Austin Ekeler is a bonafide star in the National Football League. If he stays healthy for the game, he will have a good chance of finding paydirt in what feels like a must-win for the Chargers. The Cardinals house one of the worst defenses in the game, giving the star running back a golden chance to find the endzone via the ground or the air.

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NFL Parlay Leg #2: Los Angeles Chargers QB Justin Herbert Over 281.5 Receiving Yards (-113)

The Cardinals' defense isn't outstanding, but they are slightly better against the run. Meanwhile, the Chargers are much better at throwing than running. Nevertheless, the matchup suggests that QB Justin Herbert will let it fly on Sunday afternoon. The star gun slinger is averaging 273 air yards per contest this season, and the numbers should continue to climb after Sunday's game.

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NFL Parlay Leg #3: Cardinals/Chargers Over 49.5 Total Points (-114)

The 49.5 seems high, but neither team has excelled on defense this season. Meanwhile, both offensive units have returning playmakers off of injury. The Cardinals will finally have DeAndre Hopkins and Marquise Brown active in the same game, which is perfect timing given that QB Kyler Murray is back in action.

The Chargers will welcome TE Gerald Everett back into the mix, and WR Keenan Allen seems as healthy as he has been all season. A lot of the star power in Sunday's game is on the offensive side of the ball, suggesting the over is the play.

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NFL Parlay Leg #4: Los Angeles Chargers +4.5 (-290)

The Chargers need this game. At 5-5 and trailing the Jets by one game for the final wildcard spot, a win against a 3-7 Cardinals team will keep their playoff chances alive. They match up well against Arizona and should stay in this game if they do not win it outright.

Final Odds: +409

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