Penn State Nittany Lions vs. Ohio State Buckeyes Odds, Line, Picks, and Prediction- October 29 | 2022 NCAA Football Season

If there is one game that you don't want to miss this weekend, it is Ohio State vs. Penn State. The Ohio State Buckeyes, looking for yet another Big Ten title, take their talents to Happy Valley to face off against bitter rival Penn State. The Nittany Lions faithful will be hyped up for this one, but expect Buckeye nation to match their hosts' intensity level.

The betting odds and predictions are below:

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The Ohio State Buckeyes are the most talented, explosive offenses in all College Football. Heisman Trophy front-runner C.J. Stroud plays the game with precision and accuracy.

The Buckeyes' offense boosts a 1-2 punch in the backfield of TreVeyon Henderson and Miyan Williams. Henderson can take the ball to the house on any given carry, while Williams is the thunder between the tackles who can wear down the defense.

The Buckeyes get a boost to their offense with the return of one of the top receivers in the land--Jaxson Smith-Njigba.

Penn State offers a balanced offensive attack led by QB Sean Clifford and RB Nicholas Singleton.

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Penn State Nittany Lions vs. Ohio State Buckeyes Game Details

Fixture: Ohio State Buckeyes @ Penn State Nittany Lions

Date and Time: Saturday, October 29, 12:00 PM ET

Venue: Beaver Stadium, University Park, PA

Penn State Nittany Lions vs. Ohio State Buckeyes Best Pick:

My first thought was to lean on the Ohio State running game here, but it could just as well be a Miyan Williams game as a TreVeyon Henderson game. The pivot is to lean on QB C.J. Stroud. Stroud will have his full complement of weapons in this one and should terrorize a beatable Penn State secondary.

C.J. Stroud; Passing Yards: Over 300.5

Penn State Nittany Lions vs. Ohio State Buckeyes Final Prediction

When you see Penn State vs. Ohio State on your schedule, you know it is one of the games you want to circle. The Nittany Lions have played the Buckeyes tough over the years. My pushback would be that this Ohio State team has the best balance on offense that I can remember in quite some time. The Buckeyes can beat you through the air with the right arm of QB C.J. Stroud. If the passing game struggles, they turn around and rely on their dominant rushing attack. Either way, I don't see how Penn State can match the firepower of Ohio State. The Buckeyes pull away late in this one.

Ohio State Buckeyes: -15.5 (-110)

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