10 most painful Grand Slam defeats for Roger Federer

#6 2011 Wimbledon quarter finals: Jo-Wilfried Tsonga beat Federer 3-6 6-7(3) 6-4 6-4 6-4

Tsonga became the first player to beat Federer in a Grand Slam, from a two-set deficit

After a fourth French Open final reverse against Nadal in 2011, Federer, in his ninth consecutive Wimbledon quarterfinal, was up against the big serving Jo-Wilfried Tsonga.

The Swiss rode a lone break en route to the first set and won a 7-3 tiebreak in the second to take a two-set lead. Thoughts of a defeat looked remote as Federer, after taking a two-set lead, was undefeated in his previous 178 Grand Slam matches.

Tsonga, on the day, had other ideas though. Federer saw no more break points in the remainder of the match as the Frenchman won three consecutive 6-4 sets to stun the Swiss, in the process becoming the first player to defeat Federer at a major after overhauling a two-set deficit.