#2 Rafael Nadal
Three US Opens, five Rogers Cup crowns, and one Cincinnati title, need we say any more about Rafael Nadal's prowess on the American hardcourts? Nadal has maintained a healthy record on this surface recently with one of three US Open titles and two of five Rogers Cup crowns coming in the last three years.
The Spaniard will enter the tournament with nothing but the title in his mind. Another victory at Flushing Meadows will cap off another near-perfect Grand Slam season for the 18-time major winner.
#1 Novak Djokovic
Novak Djokovic is the defending champion, the top seed and, as has been the case in the past few years, the man to beat. His record at the US Open might not be as stellar as at the other Slams, but he is a force to reckon with nonetheless.
The Serb has played in just one tournament since Wimbledon, making it to the semifinal in Cincinnati where he lost to a surging Medvedev. However, he looks in great nick and will be keen on going all the way. When on song, Djokovic is close to unstoppable and there is little that anyone can do to stop him in his tracks.
Honorable mentions
Roger Federer can never be counted out regardless of his form coming into the tournament. Others to watch out for in the draw are former champions Stan Wawrinka and Marin Cilic, as well as John Isner, Dominic Thiem, Stefanos Tsitsipas and Andrey Rublev, who have all also done well on the American hard courts in the past.
What is the foot injury that has troubled Rafael Nadal over the years? Check here