#4 Andy Murray (2012)
Murray arrived at the US Open after a title run in Brisbane, a semifinal exit against Djokovic at the Australian Open, a defeat against Federer in the Dubai final and a loss against Djokovic in the Miami title match before being thwarted in a fourth straight Grand Slam final by Federer at Wimbledon.
In his eighth appearance at the US Open, the third-seeded Murray opened his campaign with successive straight-set victories over Aleksandr Bogomolov Junior and Ivan Dodig before needing three tie-break sets to see off Spanish left-hander Feliciano Lopez in a four-set encounter.
Murray beat Raonic in straight sets in the fourth round to reach the quarter-finals where he overcame Marin Cilic in four sets. In the last-four, Murray fought back from a set deficit to oust Federer's conqueror Tomas Berdych to reach his second US Open title match (in 2008 he lost to Federer) where Djokovic awaited.
In a gruelling near five-hour battle, the Scot took a two-set lead only for the defending champion to take the next two sets and force a decider. An injured Djokovic, however, ceased to be competitive in the fifth set as Murray sprinted to the finish line to land the biggest title of his career.
In the process, Murray became the first British men's singles player since Fred Perry in 1936 to win a Grand Slam title.