‘A.P. Bio’: Full list of cast 

The NBC sitcom A.P. Bio is a comedy show that ran from 2018 to 2021 created by Michael Patrick O'Brien. The series starred Glenn Howerton, Lyric Lewis, and Mary Sohn, and spanned 42 episodes across four seasons. You can now watch the comedy sitcom streaming on Netflix this November.

A.P. Bio explored the lives of students and faculty at the fictional Whitlock High School. The show followed disgraced former philosophy professor Jack Griffin (Howerton), who begrudgingly takes a job teaching advanced placement biology. Rather than focusing on science, Griffin uses his students to scheme against those who have wronged him.

Initially airing on NBC for two seasons, the show was canceled in June 2019. However, a fan campaign, with public support from stars Glenn Howerton and Patton Oswalt, led to the show becoming the first and only series renewed for Peacock when the streaming platform launched in July 2020.

Executive producers included O'Brien himself, with Seth Meyers, Lorne Michaels, Andrew Singer, and Michael Shoemaker.

Despite its devoted following, the show was canceled in December 2021 after four seasons, but it remains one of the standout modern sitcoms today. Here’s the full list of the cast of the hit TV series.

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A.P. Bio: List of cast members

1) Glenn Howerton as Jack Griffin

A.P. Bio's Jack Griffin played by Glenn Howerton (Image via NBC)

American actor and filmmaker Glenn Howerton is best known for his portrayal of Dennis Reynolds in It’s Always Sunny in Philadelphia (2005), where he also serves as a writer and executive producer. Howerton also starred in the sitcoms That '80s Show (2002) and Fox's The Mindy Project (2012) as Cliff Gilbert.

From 2021 to 2023, Howerton co-hosted The Always Sunny Podcast alongside fellow co-creators Rob McElhenney and Charlie Day before the podcast went on hiatus.

In A.P. Bio, Howerton plays Jack Griffin, a disgraced Harvard philosophy professor who loses his dream job to his academic rival, Miles Leonard (Tom Bennett). Forced to return to his hometown of Toledo, Ohio, Griffin begrudgingly takes a position teaching advanced placement biology at Whitlock High School. He lives in his late mother’s home while teaching. Refusing to teach biology, Griffin instead enlists his honor-roll students to help him plot elaborate schemes of revenge against Miles.

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2) Lyric Lewis as Stef Duncan

Lyric Lewis as Stef Duncan (Image via Peacock)

Lyric Lewis, born in New Orleans, Louisiana, is an actress and writer known for her work in Waffles + Mochi (2021), Take One (2018), and Waffles + Mochi’s Restaurant (2022). She has also appeared in comedy series such as Brooklyn Nine-Nine (2013), Baskets (2016), iCarly (2007), Party Down (2009), and Night Court (2023).

Lewis plays Stef Duncan in A.P. Bio, a spirited history teacher at Whitlock High School. Stef is a close friend of Jack Griffin, as well as fellow teachers Mary (Mary Sohn) and Michelle (Jean Villepique). They form a supportive and humorous dynamic within the school’s faculty throughout the series.

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3) Mary Sohn as Mary Wagner

Mary Sohn as Mary Wagner (Image via Peacock)

Born in Champaign, Illinois, Mary Sohn is an actress and writer known for her roles in The Boss (2016), Between Two Ferns: The Movie (2019), and Irregular Fruit (2009).

Sohn portrays Mary Wagner, an art teacher at Whitlock High School. She is close friends with Jack, Stef, and Michelle. Vain about her appearance, Mary humorously encourages her students to create flattering, overly seductive drawings of her. Alongside Stef, she frequently pokes fun at Principal Durbin (Patton Oswalt) and Michelle, while also teasing Jack about his lack of self-awareness in a way that remains endearing.

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Other members of the cast

In addition to its main characters, A.P. Bio features an ensemble of supporting cast members who bring the halls of Whitlock High School to life.

• Jean Villepique as Michelle Jones
• Patton Oswalt as Principal Ralph Durbin
• Aparna Brielle as Sarika
• Nick Peine as Marcus
• Allisyn Snyder as Heather
• Eddie Leavy as Anthony
• Jacob Houston as Victor
• Sari Arambulo as Grace
• Spence Moore II as Dan Decker
• Paula Pell as Helen Henry Demarcus
• Marisa Baram as Marissa
• Miguel Lee as Eduardo
• Jacob Timothy Manown as Caleb
• Charlie McCrackin as Dick Novak, Coach, Coach Novak
• David Neher as Dave

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Don’t miss the chance to enjoy A.P. Bio’s every episode now streaming on Netflix this November.