3 active wrestlers John Cena has never beaten in WWE and 3 he is undefeated against

#1 John Cena is undefeated against Rey Mysterio (2-0)

It was the high-flying @reymysterio vs. the ruthless aggression of @JohnCena ON THIS DAY in 2003! pic.twitter.com/ZNDUVsMetP

— WWE (@WWE) November 6, 2017

John Cena has had some legendary battles against veteran superstars since the mid-2000s. He shared intense rivalries with Randy Orton, Edge, and Batista. However, Cena has barely faced off against another legendary figure from the Ruthless Aggression Era - Rey Mysterio.

The 16-time world champion has only had two singles matches against the masked superstar. John Cena's first match against Mysterio came on a November 2003 episode of SmackDown.

In a more consequential one, the two ultra-babyfaces faced each other in a WWE Championship match in July 2011. Rey Mysterio had just won the belt at the start of an episode of RAW but had to defend it against Cena later that night.

#ONTHISDAY - July 25th, 2011 - Rey Mysterio wins the WWE Championship, only to lose it to John Cena on the same night, who would THEN be interrupted by the returning and existing WWE Champion, CM Punk! #wwe #wrestling #reymysterio #johncena #cmpunk #championship #july25 pic.twitter.com/3Llc8yt1YK

— The Heel Factor (@TheHeelFactor) July 25, 2018

The Leader of the Cenation won the WWE Title after a competitive match. He would be interrupted by CM Punk, who returned to WWE eight days after "leaving" the company at Money in the Bank.

John Cena and Rey Mysterio were back on the same team during a dark match following this week's episode of SmackDown.