#1. Randy Orton disrespects Eddie Guerrero
The road to WrestleMania 22 was an emotional ride for Rey Mysterio, as he had won the Royal Rumble match after dedicating his eventual win to his longtime friend, the late, great Eddie Guerrero.
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Randy Orton, the man who was thrown out of the ring by Rey to win the Rumble, immediately began getting into Rey's head, in order to lure him into putting his title shot at WrestleMania on the line. This led to one of the most tasteless segments in SmackDown history, where Orton did the unthinkable.
As a devastated Mysterio was talking about Eddie Guerrero, Orton interrupted him and went on to state that Eddie wasn't in Heaven, but he was down in Hell.
Fans gasped in unison and booed the living daylights out of Orton. Mysterio gave him a low blow, with the rivalry culminating at 'Mania as Rey Mysterio won the World Heavyweight title by pinning Orton. This moment was never mentioned again on WWE TV and for good reason.