#1 Randy Orton
John Cena vs Randy Orton is the marquee match of an era deprived of The Rock vs Austin rivalry. Cena vs Orton is one of the longest standing rivalries in the history of WWE.
As two of the most promoted stars of the company, Cena and Orton facing off has always had an epic and nostalgic feel to it. They work well together as a result of being paired together numerous times. Their in-ring chemistry shows the practised sleekness that comes from years of facing each other in the ring.
Gimmick wise, Randy Orton and John Cena were perfectly suited to square off against each other. The Viper is always at his best when playing up his villainous tendencies and Cena loves to play up his Superman persona. Orton provided the perfect demented adversary for Cena to vanquish. A perfectly balanced heel and face combo, this pair had greatness written all over it.
They've had some intense collisions over time and it would be hard to pick a favourite. Their "I Quit" match at WWE Breaking Point is a prime example of this. The vicious and brutal nature of Orton's heel persona is at full display here as he handcuffs Cena to beat him down to size. On the other hand, Cena meets him head on with a never give up attitude and employs all the moves in his arsenal to get the win.
The thing that makes this rivalry stand apart from all the others is how deeply personal it got at times. The Viper made things personal when he attacked Cena's dad and punted him. John Cena Sr. even went on to have a match against Orton!
Overall, it is the back and forth between these two that makes this rivalry enjoyable. Neither wrestler has dominantly overpowered the other and it's always a luck of the draw as to who will come out on top.