#2. It would be a great way to push Big E into the main event without having to wait for the Roman Reigns and John Cena feud to finish
Big E is the current Mr. Money in the Bank after winning the Money in the Bank Ladder match, however, given that WWE seems poised to have Roman Reigns vs. John Cena at SummerSlam for the title, it seems he won't be cashing in on SmackDown anytime soon. Unless, of course, WWE doesn't.
There's a scenario where Big E cashes in on Reigns before the Tribal Chief is due to take on John Cena at SummerSlam. Perhaps he does so after the Finn Balor match, perhaps Cena attacks Reigns, or perhaps the Usos turn on Reigns. Essentially there are many ways you can have Big E cash in successfully on Reigns without hurting him too much.
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WWE could then have Big E defending a world title at SummerSlam, which would be a huge moment for him and keep their big marquee match between John Cena and Roman Reigns. It's a win-win
#1. It would be a massive shock to the WWE Universe for Roman Reigns to lose the title.
Roman Reigns is undefeated in 2021 and looks set to continue willing well into next year. Consequently no-one truly believes that Reigns will truly lose the Universal Title, against Finn Balor or John Cena.
But that's exactly why WWE should consider having Reigns lose his title before taking on John Cena, because it's the last thing anyone would expect and it would lead to a big moment for the WWE Universe and intriguing storyline steps to follow.