5 Superstars who could defeat Rey Mysterio for the United States Championship 

#4 Randy Orton

Mysterio owes him a favor.

One of the only reasons why Rey Mysterio became United States Champion was because of Randy Orton's interference. Orton has a bone to pick with AJ Styles and The OC and he assisted Mysterio in gaining two key victories over 'The Phenomenal One' to win and hold on to the title. After 'The Viper' is done with Styles, he could turn back to Mysterio and demand a title shot in exchange for his 'generosity.'

Randy Orton is at that stage in his career where he is beyond babyface and heel, playing whatever character he feels like. This is a realistic enough storyline which could work, as we head into the most important few months on the WWE calendar. Both, Mysterio and Orton are legendary names who could lend a lot of prestige to the United States Championship.

The two faced off a number of times around a year ago on SmackDown Live, including in an entertaining Chairs Match at the TLC event. Mysterio picked up the upset victory that time, so Orton could possibly strike back and take the United States Title for himself. It has been a while since the former Evolution member has had a proper championship reign that lasted longer than a couple of months.