#2 John Cena (25)
Arguably the greatest Superstar in WWE history, John Cena's career has been defined by his 16 World Championship reigns, a record only tied by Ric Flair.
Winning his first world championship at WrestleMania 21, the Superstars who have lost a world title to him reads like a who's who: JBL, Edge, Randy Orton, AJ Styles, Chris Jericho and more.
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Outside of the main event, Cena has also held four tag titles, with four different partners (Shawn Michaels, Batista, The Miz and David Otunga), though none of these reigns lasted very long.
A four-time United States Champion, Cena first held the star-spangled strap at WrestleMania 20, toppling The Big Show to do so, and when you factor in his two Royal Rumble and multiple WrestleMania main events, Big Match John has certainly lived up to his name.