5 WWE Tag Team Champions who have faced off in a one-on-one match 

#2. Eddie Guerrero and Rey Mysterio

Rey Mysterio faced off against Eddie Guerrero back at WrestleMania 21

Rey Mysterio and Eddie Guerrero were close friends both inside and outside of WWE, which could be why they were able to have such a fantastic feud throughout 2005 regarding the real paternity of Mysterio's son Dominick.

Ahead of this headline feud, which reached its climax in a ladder match at SummerSlam the same year, Eddie Guerrero and Rey Mysterio won the Tag Team Championships at No Way Out when they were able to defeat The Basham Brothers.

Despite being Tag Team Champions, Eddie Guerrero and Rey Mysterio still faced off at WrestleMania 21 where Mysterio was able to pick up the win with a fluke roll-up.

Interestingly the two men were still able to shake hands after the match even though the problems between them were just beginning. Their match for the custody of Dominick took place just four months later at The Biggest Party of the Summer and much like their WrestleMania match it was Mysterio who was able to come out on top and maintain the custody of his son, who is currently working for WWE alongside his legendary father.