#3 Roman Reigns defeated Brock Lesnar in 2018 to win the Universal Championship
Roman Reigns and Brock Lesnar have had a few noteworthy feuds in WWE, the first of which began in 2015. At WrestleMania 31, Lesnar was the champion going into a singles match with Reigns, before Seth Rollins cashed in his contract to win the title. The two faced each other once again a year later in a triple threat match that also involved Dean Ambrose.
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Reigns didn't pin Lesnar in that match as he got the win after spearing Ambrose to get the win. At SummerSlam 2017, the two were once again in the same ring, this time in a fatal four-way match also involving Braun Strowman and Samoa Joe. Reigns was pinned by Brock Lesnar in this match, which resulted in Lesnar retaining his title.
Lesnar then defeated Reigns twice in 2018, first at WrestleMania 34, followed by a win at the Greatest Royal Rumble in Saudi Arabia. The Tribal Chief, though, had the final laugh in that feud as he defeated Brock Lesnar at SummerSlam 2018 to win the Universal title for the very first time.