#1. Mickie James

Mickie James is considered to be a veteran in the WWE Women's Division as a former six-time Women's Champion, but after recently being underutilized by the company, she revealed as part of an Instagram live stream that she had suffered an ACL injury that would require surgery.
James suffered the injury back in June as part of a live event match against Carmella and went on to undergo surgery back in July. James has since Tweeted to state that surgery was successful but her expected recovery time is around 7-9 months, this means that the former Women's Champion is expected to be sidelined until at least February next year.
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James could be targetting WrestleMania season next year for her return since it's more likely that she could need the nine months recovery time at this stage in her career.