2) Unforgiven (2006): WWE championship (reign #3)
This was Cena's longest title reign in his career. He held on to the title for a mammoth 380 days. He defeated Edge in one of the best Tables, Ladders, and Chairs matches of all time to clinch his third world title reign. That match included a memorable spot where Cena AA'ed Edge from top of a ladder through a stacked table.
He defended his title against the likes of Umaga, Randy Orton, Edge, Shawn Michaels, Great Khali, and Mick Foley. One of the most memorable matches in the list was his Wrestlemania 23 bout against Shawn Michaels which, to this day, arguably remains Cena's best Wrestlemania match.
However, before his title defense against Randy Orton at No Mercy (2007), he tore his right pectoral muscle, causing him to relinquish the title.