#1 Edge cashes in (2006)
The greatest moment in Elimination Chamber history actually did not happen within the confines of the unforgiving steel structure. Instead, it happened after one such match. At the start of 2006, John Cena was dominating the Raw brand and defended his WWE Championship inside the Chamber. He started the match and ended up victorious but just as it looked like another day in the office for Cena, Mr McMahon came out and announced that Edge was cashing in his Money in the Bank contract. This was the first ever Money in the Bank cash-in, making this an even bigger deal than it already was.
Edge walked down to the ring with Lita and kicked Cena around, before eventually pinning him to win his first world title, the first of many. It was a crazy moment, a revolutionary one in terms of laying the blueprint for future cash-ins. This was the Ultimate Opportunist at his absolute best, the making of the Rated R Superstar. No cash-in would top this until WrestleMania 31, that's how good this was. It also perfectly sold the damage that the Elimination Chamber can do, even to the victor. There may never be another Chamber related moment as cool as this.