United States Champion: Samoa Joe
We don't know his challenger(s) yet, but full-stop, Samoa Joe isn't losing his title. If there's anybody capable of bringing the US title back from the brink it's been in for the past year plus, he's the one. Leaving the title on Joe for a while would restore its credibility.
Likely challengers include the three men he's been battling for the past few weeks, but either way, none of them appears ready to beat him now. More interesting feuds await with the Superstar Shakeup.
Intercontinental Champion: Finn Balor
There's a rash of speculation about why Finn Balor lost the Intercontinental Championship this week, but there's nothing concrete to any of those rumors. The likeliest scenario is still Balor going after the Intercontinental Championship in a multi-man scenario, maybe including Baron Corbin and Braun Strowman.
Balor is a strong candidate to move to SmackDown after the Superstar Shakeup, but the mid-card titles have moved in the past, so his winning the title wouldn't stop him from doing that.
This one is on the knife edge, but I slightly favor it changing hands at WrestleMania.