Phillies vs. Mets: Game 1, prediction, odds, injuries and picks

Phillies vs. Mets: Game 1, prediction, odds, injuries and picks - April 21, MLB 2025

Modified Apr 21, 2025 14:18 GMT

MLB: St. Louis Cardinals at New York Mets - Source: Imagn — Juan Soto, New York Mets - Source: Imagn

National League East Division rivals the Philadelphia Phillies and New York Mets will kick off a huge series on Monday. Both Philadelphia and New York have gotten off to a great start this season, and this should be an excellent matchup.

Odds for this game have been set, and there are a number of different ways to predict the series opener. Here is a look at this game and a prediction for how this game will play out.

Phillies vs. Mets prediction

Aaron Nola is pitching today - Source: Imagn

Aaron Nola will be on the mound for the Phillies to begin this series, and he is looking to bounce back after a slow start. Nola is 0-4 with a 6.65 ERA this season, but he's been a dominant pitcher over the last few seasons.

Kyle Schwarber is having a huge season for the Phillies as he has belted seven home runs and leads the team with 16 RBIs. Other sluggers on this team have struggled to begin the year, and this is something to watch.

Pete Alonso is having a huge season for the Mets as he leads the team with six home runs and 24 RBIs. Juan Soto and Francisco Lindor are still trying to get going, but they can break out at any time.

This should be a low-scoring affair, and that is going to favor the Mets. Expect New York to score just enough to pick up a win over their division rivals.

Prediction: New York Mets 4, Philadelphia Phillies 3

Phillies vs. Mets odds

Money Line: Philadelphia Phillies +105, New York Mets -125

Run Spread: Phillies +1.5 (-200), Mets -1.5 (+165)

Total Runs: Over 7.5 (-120), Under 7.5 (EVEN)

Phillies vs. Mets injuries

Philadelphia Phillies injury report

Brandon Marsh (CF): 10-Day IL (Right hamstring strain)

Ranger Suarez (LHP): 15-Day IL (Lower back stiffness)

Weston Wilson (UTIL): 15-Day IL (Mild oblique strain)

New York Mets injury report

Jeff McNeil (2B): 10-Day IL (Right oblique strain)

Francisco Alvarez (C): 10-Day IL (Fractured left hamate bone)

Mark Vientos (3B): Day-to-Day (Groin discomfort)

Jose Siri (OF): 10-Day IL (Fractured left tibia)

Frankie Montas (RHP): 15-Day IL (Lat strain)

Phillies vs. Mets picks

Francisco Lindor, New York Mets - Source: Imagn

This should be a great series in New York, and the home team will pick up a win in the series opener. Expect a very close game as the pitching staff will set the tone for the series opener.

Money Line: New York Mets -125

Run Spread: Phillies +1.5 (-200)

Total Runs: Under 7.5 (EVEN)

About the author

Ryan Burks is a baseball journalist at Sportskeeda with over 7 years of experience in the field, writing for publications such as Knup Sports. Ryan graduated from Elmhurst College in 2009 with a degree in Communications.

Ryan is a huge Chicago Cubs fan and enjoys their storied history and traditions. His favorite sporting moment was when the Cubs won the 2016 World Series, breaking a championship drought that dated back to 1908.

His favorite player was Ken Griffey Jr., as Ryan grew up during his prime and he was the coolest player in league history. Greg Maddux also deserves a mention, as he was truly amazing on the mound.

When not working or watching sports, Ryan coaches basketball and baseball, loves fishing, and spends time with his family.

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Edited by Ribin Peter