The First Descendant Python build guide: Modules, Unique Trait, and more

The Python in The First Descendant is an Ultimate Submachine Gun with a powerful special ability that applies a debuff to targets, significantly increasing your damage output. Although crafting Ultimate Weapons requires rare materials, you don't have to keep crafting new ones if the affixes aren't optimal for your build. Instead, you can use the Weapon Readjustment mechanic to lock the desirable affixes and reroll the others until you have the ideal weapon.

This guide covers everything to know about Python in The First Descendant, including how to craft it.

Note: Some aspects of this article are subjective and solely reflect the writer's opinion.

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How to get Python in The First Descendant

You can craft Python at the Research Institute (Image via Nexon)

You can obtain Python by researching it in Albion with the help of Magister Anais in The First Descendant. Here are the requirements for crafting this Submachine Gun, including the time, cost, materials, and Mastery Rank:

• Research Time: Four Hours
• Research Cost: 100,000 Gold
• Mastery Rank: Research Available at Rank 10

Research Material

• 1x Python Polymer Syncytium Blueprint
• 1x Python Synthetic Fiber Blueprint
• 1x Python Nano Tube Blueprint
• 1x Python Blueprint

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Best Python build in The First Descendant

Python base stats in The First Descendant (Image via Nexon)

Inflicting damage to a target's Weak Point with the Python in The First Descendant activates its special ability, Python Instinct, which applies the Prey debuff. This debuff significantly reduces the target's DEF and Toxic Resistance.

Python can be used by any character, as the DEF reduction part of the debuff will significantly increase your damage output regardless of the damage type. Additionally, you can take advantage of the reduced Toxic Resistance on enemies by using a Toxic Enhancement Module on the weapon.

That said, the Python in The First Descendant is best suited for Freyna builds, as all her abilities inflict Toxic damage on enemies.

Here are the best Modules for Python in The First Descendant:

• Fire Rate Up (Xantic): Increases your Fire Rate.
• Rifling Reinforcement (Malachite): Increases your Firearm ATK.
• Poison Priority (Rutile): Increases your Toxic ATK and Reload Time.
• Weak Point Aiming (Rutile): Increases your Accuracy and Weak Point Damage.
• Action and Reaction (Malachite): Increases your Firearm ATK and reduces Recoil.
• Weak Point Sight (Malachite): Increases your Firearm Critical Hit Rate and Weak Point Damage.
• Better Insight (Almandine): Increases your Firearm Critical Hit Rate.
• Mental Focus (Malachite): Decreases your Base Fire Rate while significantly increasing your Firearm ATK.
• Toxic Enhancement (Rutile): Adds Toxic ATK equal to a percentage of your Firearm ATK. You can also swap this module when facing a boss resistant to Toxic attack.

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Check out our other guides on The First Descendant:

• How to defeat the Hanged Man boss in The First Descendant
• The First Descendant Complete Bunny questline: All Record locations
• The First Descendant Thunder Cage build: Best Modules, unique trait, and more
• All Ultimate Descendants and how to get them