The original Synapse is one of the more underrated single-target specialists in Warframe, and the Coda Synapse is a big upgrade over it. This is a beam weapon that doesn't chain but has some innate Punch Through to work with. This, on top of added base damage through Progenitor and noteworthy crit chance, makes the Coda Synapse easily viable for level-cap Disruption runs.
Thanks to the providence of Valence Override through Elemental Vice in Warframe, you can now juggle between multiple Coda Synapse builds. In this guide, we'll go over multiple build setups and synergies that can elevate the Synapse to a truly S-tier Coda weapon.
For the purposes of Demo-unit killing, these builds will also work perfectly with the regular Synapse.
Endgame Coda Synapse build in Warframe (5-Forma)
With a 5-Forma setup, we'll go over multiple Coda Synapse builds depending on what Warframe and Progenitor bonus you plan on running. After you unlock Exilus Slot, swap the Forma to make it neutral and get a free V polarity (otherwise this would technically be a 7-Forma setup).
Min-maxed Coda Synapse setup (Primary Blight/Frostbite/Crux)

In this build, you want one of the following Progenitors:
- Toxin for Primary Blight
- Cold for Primary Frostbite
- Electricity for Primary Crux
Mods used:
- Exilus: Sinister Reach
- Galvanized Chamber
- Galvanized Scope
- Galvanized Aptitude
- Vital Sense
- Critical Delay
- Serration (or Spectral Serration if you have invisibility)
- Hammer Shot or Rifle Elementalist
- Primed faction damage multiplier mod
- Critical Delay (or Vile Acceleration if you're running a crit-boosting Warframe)
For the biggest bang for your buck, run it with Gyre and Conductive Sphere, the new Warframe Augment mod added in Techrot Encore, plus a few Violet Archon Shards with the +Primary Damage modifier. This build does not have innate Viral, so you need to run Nourish or a secondary source of priming (Sentinels or primer pistol).
Simpler Coda Synapse build with innate Viral-Heat

For this Coda Synapse setup, you ideally want a Heat Progenitor. The Arcane can be either Primary Merciless or Primary Crux (the latter may require a damage buff for the best results).
Mods used:
- Exilus: Sinister Reach
- Galvanized Chamber
- Galvanized Scope
- Galvanized Aptitude
- Vital Sense
- Rifle Elementalist
- Malignant Force
- Rime Rounds
- Hellfire
You can also run a Heat-inherit primer secondary and 2x Emerald Archon Shards for full strip if you're planning to do Demolisher units, but so far, I haven't needed this, even in level-cap.
A note on Rivens: If you have a good Riven and don't care much about Punch Through (a non-factor for all five people who play Qorvex), it's best to stick with the regular Synapse for now. Since the Coda Synapse was only released recently, its Riven Disposition is so low that slottable Rivens are hard to get.
Check out our other guides on the game:
- All Warframes tier list
- Warframe Incarnon weapons tier list
- Warframe Kuva weapons tier list
- Best weapons in Warframe for each Mastery Rank
- Warframe Baro Ki'teer inventory