2021 NFL Schedule: 3 key games for every AFC team in the regular season

Jacksonville Jaguars vs Indianapolis Colts

Indianapolis Colts

The Colts look primed for a successful 2021 NFL season, as they have reunited former first-round NFL draft pick Carson Wentz with head coach Frank Reich. If the QB can rediscover his early success in Philadelphia, the Colts will likely be playoff-bound.

Here are three key regular-season games for the Colts:

Week 1 - Sunday, September 12, Seattle Seahawks, 1.00 PM ET, FOX

Wentz and the Colts will look to start their new stint in Indianapolis with a big home win over the competitive Seattle Seahawks.

Week 7 - Sunday, October 24, at San Francisco 49ers, 8.20 PM ET, NBC

The Colts will travel to the Bay for a Sunday night football matchup against the 49ers. A road win in front of a national NFL audience would help them make an impressive statement.

Week 18 - Sunday, January 9, at Jacksonville Jaguars, 1.00 PM ET, CBS

Their last game of the NFL regular season will see the Colts head to Jacksonville. This is a must-win game for the Colts if they expect to make the playoffs.

Jacksonville Jaguars

It’s a new era in Jacksonville. With rookie QB Trevor Lawrence under center, the Jags will expect big things in the next few NFL seasons.

Here are three games the Jags can win in 2021:

Week 1 - Sunday. September 12, at Houston Texans, 1.00 PM ET, CBS

The Jaguars could struggle to win many games on the road this season, but their first game at Houston will likely be an opportunity for the young team to grab a Week-1 victory.

Week 16 - Sunday, December 26, at New York Jets, 1.00 PM ET, CBS

The battle of the rookie QBs will take place in Week 16. It remains to be seen whether Zach Wilson or Trevor Lawrence wins the rookie bragging rights.

Week 18 - Sunday, January 9, Indianapolis Colts, 1.00 PM ET, CBS

Their last game of the NFL regular season will see the Colts head to Jacksonville. It'll be an opportunity for the Jags to finish their season on a high, with a win in front of their home fans.

Tennesee Titans

The Titans have made the playoffs in both their last two NFL campaigns. They will look to Ryan Tannehill and Derek Henry to lead the team to another postseason.

Here are three key games for them:

Week 3 - Sunday, September 26, Indianapolis Colts, 1.00 PM ET, CBS

The Titans will look to impose their superiority over AFC South rivals, the Colts, with a home win in Week 3.

Week 16 - Thursday, December 23, San Francisco 49ers, 8.20 PM ET, NFLN

Tennessee will troop out in front of a national NFL audience in Week 16 against the 49ers.

Week 18 - Sunday, January 9, at Houston Texans, 1.00 PM ET, CBS

Ryan Tannehill and the Titans will travel to Houston for a key away game in Week 18. A win over the Texans in the final game of their regular season could secure a high playoff seed for the Titans.

Houston Texans

Things are a mess in Houston. That's because Deshaun Watson's situation shows no signs of getting resolved any time soon, and there’s a real chance he may never play for the Texans again.

Here are three key games for the Texans in what could likely be a disappointing 2021 NFL season:

Week 1 - Sunday. September 12, Jacksonville Jaguars, 1.00 PM ET, CBS

The Texans should look to win their week-one clash with the young Jags team. If the Texans can’t defeat Jacksonville at home, it could be a long season for the team.

Week 7 - Sunday, October 24, at Arizona Cardinals, 4.25 PM ET, CBS

The Texans will look at their Week 7 trip to Arizona as an opportunity for a road win in 2021, as a victory away from Houston could kickstart the Texans’ season.

Week 18 - Sunday, January 9, Tennessee Titans, 1.00 PM ET, CBS

Their last home game of the season against the Titans could be an opportunity for the Texans to give their fans some hope for 2022.