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3) 6-33 vs San Francisco 49ers, 2020-21 regular season
Thw year 2020 marked a new era for Bill Belichick and the New England Patriots. Tom Brady was gone, having taken his talents to Southwest Florida, so Cam Newton was brought in to be the new offensive leader.
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In Week 7, the Patriots welcomed back Brady's former one-time backup Jimmy Garoppolo, who by then was having a career renaissance with the San Francisco 49ers.
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However, what was expected to be an emotional game turned ugly. Jeff Wilson simply overran the hosts with three rushing touchdowns, which more than compensated for Garoppolo's scoreless night.
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