Monday, September 26, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Ronnie Stanley | OT | Mon, Sep 26 | Ankle | Questionable for Week 4 vs. Buffalo |
| James Proche | WR | Mon, Sep 26 | Groin | Questionable for Week 4 vs. Buffalo |
Sunday, September 25, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Justin Houston | OLB | Sun, Sep 25 | Groin | Questionable for Week 4 vs. Buffalo |
| Michael Pierce | NT | Sun, Sep 25 | Arm | Questionable for Week 4 vs. Buffalo |
| Patrick Mekari | OT | Sun, Sep 25 | Ankle | Questionable for Week 4 vs. Buffalo |
| Trent Harris | LB | Sun, Sep 25 | Undisclosed | Questionable for Week 4 vs. Buffalo |
Friday, September 23, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Steven Means | LB | Fri, Sep 23 | Achilles | IR. Injured Reserve |
Wednesday, September 21, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Kyle Fuller | CB | Wed, Sep 21 | Knee - ACL | IR. Injured Reserve |
Monday, September 19, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Josh Ross | LB | Mon, Sep 19 | Foot | IR. Injured Reserve. | Week 7 |
Wednesday, September 14, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Tyus Bowser | LB | Wed, Sep 14 | Achilles | Physically Unable to Perform. | Week 5 |
Tuesday, September 13, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Ja'Wuan James | OT | Tue, Sep 13 | Achilles | IR. Injured Reserve |
Thursday, September 8, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Gus Edwards | RB | Thu, Sep 8 | Knee - ACL | Physically Unable to Perform. | Week 5 |
Tuesday, September 6, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| David Ojabo | LB | Tue, Sep 6 | Achilles | NFI-R for Week 4 vs. Buffalo |
Thursday, September 1, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Vince Biegel | LB | Thu, Sep 1 | Achilles | IR. Injured Reserve | - |
| Charlie Kolar | TE | Thu, Sep 1 | Sports Hernia | IR. Injured Reserve. | Week 5 |
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