Buffalo Bills Cuts for 2022-2023 Season
| DATE | PLAYER | POSITION | TRANSACTION |
| Sep 26, 2022 | Bobby Hart | OT | Suspension lifted |
| Sep 26, 2022 | Prince Emili | DT | Cut |
| Sep 26, 2022 | Ja'Marcus Ingram | DB | Pract. squad add |
| Sep 26, 2022 | Greg Mancz | C | Pract. squad add |
| Sep 24, 2022 | Brandin Bryant | DT | Active/prac. squad |
| Sep 24, 2022 | Micah Hyde | SS | On IR neck |
| Sep 24, 2022 | Prince Emili | DT | Active/prac. squad |
| Sep 24, 2022 | Greg Mancz | C | Active/prac. squad |
| Sep 24, 2022 | Ja'Marcus Ingram | DB | Active/prac. squad |
| Sep 21, 2022 | Raheem Blackshear | RB | Pract. squad del |
| Sep 21, 2022 | Tanner Gentry | WR | Pract. squad add |
| Sep 20, 2022 | Bobby Hart | OT | Suspended 1 game (Unsportsmanlike Conduct Rule) |
| Sep 20, 2022 | C.J. Brewer | DT | Pract. squad add |
| Sep 20, 2022 | Brandin Bryant | DT | Pract. squad add |
| Sep 19, 2022 | Brandin Bryant | DT | Active/prac. squad |
| Sep 19, 2022 | C.J. Brewer | DT | Active/prac. squad |
| Sep 14, 2022 | Tanner Gentry | WR | Pract. squad del |
| Sep 14, 2022 | Prince Emili | DT | Pract. squad add |
| Sep 7, 2022 | Emmanuel Sanders | WR | Retired |
| Sep 7, 2022 | Dawson Knox | TE | Re-signed Four-year extension (through 2026) |
| Sep 2, 2022 | Kyler McMichael | DB | Pract. squad add |
| Sep 2, 2022 | Zach Davidson | TE | Pract. squad add |
| Sep 2, 2022 | Ryan Van Demark | OT | Pract. squad add |
| Aug 31, 2022 | Joe Giles-Harris | LB | Pract. squad add |
| Aug 31, 2022 | Alec Anderson | OT | Pract. squad add |
| Aug 31, 2022 | Brandin Bryant | DT | Pract. squad add |
| Aug 31, 2022 | Sam Martin | P | Signed One-year contract (through 2022) |
| Aug 31, 2022 | Mike Love | DE | Pract. squad add |
| Aug 31, 2022 | Isaiah Hodgins | WR | Pract. squad add |
| Aug 31, 2022 | Duke Johnson | RB | Pract. squad add |
| Aug 31, 2022 | Ja'Marcus Ingram | DB | Pract. squad add |
| Aug 31, 2022 | Tavon Austin | WR | Pract. squad add |
| Aug 31, 2022 | Marquez Stevenson | WR | On IR foot surgery |
| Aug 31, 2022 | Tanner Gentry | WR | Pract. squad add |
| Aug 31, 2022 | Matt Barkley | QB | Pract. squad add |
| Aug 31, 2022 | Greg Mancz | C | Pract. squad add |
| Aug 31, 2022 | Raheem Blackshear | RB | Pract. squad add |
| Aug 31, 2022 | C.J. Brewer | DT | Pract. squad add |
| Aug 30, 2022 | Nick McCloud | CB | Cut |
| Aug 30, 2022 | Alec Anderson | OT | Cut |
| Aug 30, 2022 | O.J. Howard | TE | Cut |
| Aug 30, 2022 | Luke Tenuta | OT | Cut |
| Aug 30, 2022 | C.J. Brewer | DT | Cut |
| Aug 30, 2022 | Kingsley Jonathan | DE | Cut |
| Aug 30, 2022 | Eli Ankou | DT | Cut |
| Aug 30, 2022 | Matt Barkley | QB | Cut |
| Aug 30, 2022 | Tre'Davious White | CB | Placed on PUPL left knee |
| Aug 30, 2022 | Prince Emili | DT | Cut |
| Aug 30, 2022 | Joe Giles-Harris | LB | Cut |
| Aug 30, 2022 | Ja'Marcus Ingram | DB | Cut |
| Aug 30, 2022 | Mike Love | DE | Cut |
| Aug 30, 2022 | Raheem Blackshear | RB | Cut |
| Aug 30, 2022 | Brandin Bryant | DT | Cut |
| Aug 30, 2022 | Isaiah Hodgins | WR | Cut |
| Aug 30, 2022 | Tanner Gentry | WR | Cut |
| Aug 30, 2022 | Duke Johnson | RB | Cut |
| Aug 30, 2022 | Greg Mancz | C | Cut |
| Aug 29, 2022 | Jacob Capra | OG | Cut |
| Aug 29, 2022 | Daniel Joseph | DE | Cut |
| Aug 29, 2022 | Jordan Miller | DB | Cut |
| Aug 29, 2022 | Josh Thomas | DB | Cut |
| Aug 29, 2022 | Neil Pau'u | WR | Cut |
| Aug 29, 2022 | Tanner Owen | OT | Cut |
| Aug 27, 2022 | Matt Araiza | P | Cut |
| Aug 23, 2022 | Ike Boettger | OG | Placed on PUPL Achilles |
| Aug 22, 2022 | Matt Haack | P | Cut |
| Aug 22, 2022 | Tavon Austin | WR | Cut |
| Aug 16, 2022 | Tim Harris | CB | Cut |
| Aug 16, 2022 | Marquel Lee | MLB | Cut |
| Aug 14, 2022 | Jalen Wydermyer | TE | Cut |
| Aug 14, 2022 | Derek Kerstetter | OT | Cut |
| Aug 14, 2022 | Jordan Simmons | OG | Cut |
| Aug 14, 2022 | Olaijah Griffin | CB | Cut |
| Aug 7, 2022 | Reggie Gilliam | FB | Re-signed Two-year extension (through 2024) |
| Jul 30, 2022 | Jordan Miller | DB | Signed |
| Jul 30, 2022 | Travon Fuller | DB | Cut |
| Jul 25, 2022 | Jordan Simmons | OG | Signed/unrest FA One-year contract (through 2022) |
| Jun 17, 2022 | Jake Kumerow | WR | Signed |
| Jun 16, 2022 | Jake Kumerow | WR | Cut |
| Jun 13, 2022 | Greg Van Roten | OG | Signed One-year contract (through 2022) |
| Jun 8, 2022 | Will Ulmer | OT | Cut |
| Jun 5, 2022 | Tavon Austin | WR | Signed/unrest FA |
| Jun 3, 2022 | Malik Williams | WR | Cut |
| Jun 2, 2022 | Andre Smith | LB | Suspended 6 games (NFL Policy on PEDs) |
| May 17, 2022 | Daniel Joseph | DE | Signed |
| May 16, 2022 | Will Ulmer | OT | Signed |
| May 16, 2022 | C.J. Brewer | DT | Signed |
| May 16, 2022 | Ja'Marcus Ingram | DB | Signed |
| May 16, 2022 | Prince Emili | DT | Signed |
| May 14, 2022 | Travon Fuller | DB | Signed |
| May 13, 2022 | Alec Anderson | OT | Signed |
| May 13, 2022 | Raheem Blackshear | RB | Signed |
| May 13, 2022 | Derek Kerstetter | OT | Signed |
| May 13, 2022 | Khalil Shakir | WR | Signed/draft choice Four-year contract (through 2025) |
| May 13, 2022 | Kaiir Elam | CB | Signed/draft choice Four-year contract (fifth-year option) |
| May 13, 2022 | James Cook | RB | Signed/draft choice Four-year contract (through 2025) |
| May 13, 2022 | Malik Williams | WR | Signed |
| May 13, 2022 | Jalen Wydermyer | TE | Signed |
| May 13, 2022 | Christian Benford | CB | Signed/draft choice Four-year contract (through 2025) |
| May 13, 2022 | Matt Araiza | P | Signed/draft choice Four-year contract (through 2025) |
| May 13, 2022 | Tanner Owen | OT | Signed |
| May 13, 2022 | Neil Pau'u | WR | Signed |
| May 13, 2022 | Kingsley Jonathan | DE | Signed |
| May 13, 2022 | Luke Tenuta | OT | Signed/draft choice Four-year contract (through 2025) |
| May 12, 2022 | Baylon Spector | LB | Signed/draft choice Four-year contract (through 2025) |
| May 12, 2022 | Terrel Bernard | LB | Signed/draft choice Four-year contract (through 2025) |
| Apr 26, 2022 | Ed Oliver | DT | Team exercises option Fifth-year option on rookie contract |
| Apr 21, 2022 | David Quessenberry | OT | Signed/unrest FA One-year contract (through 2022) |
| Apr 11, 2022 | Bobby Hart | OT | Re-signed/unrest FA One-year contract (through 2022) |
| Apr 6, 2022 | Stefon Diggs | WR | Re-signed Four-year extension (through 2027) |
| Apr 4, 2022 | Taiwan Jones | RB | Re-signed/unrest FA One-year contract (through 2022) |
| Apr 1, 2022 | Christian Wade | RB | Cut |
| Mar 29, 2022 | Ryan Bates | OG | Matched Offer Sheet Four-year contract (through 2025) |
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