Monday, September 26, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Jordan Poyer | FS | Mon, Sep 26 | Foot | Questionable for Week 4 at Baltimore | - |
| Mitch Morse | C | Mon, Sep 26 | Elbow | Questionable for Week 4 at Baltimore | - |
| Jordan Phillips | DT | Mon, Sep 26 | Hamstring | Questionable for Week 4 at Baltimore | - |
| Dane Jackson | CB | Mon, Sep 26 | Neck | Questionable for Week 4 at Baltimore | - |
| Ryan Bates | OG | Mon, Sep 26 | Concussion | Questionable for Week 4 at Baltimore | - |
| Tommy Doyle | OT | Mon, Sep 26 | Knee - ACL | Out for Week 4 at Baltimore | - |
| Ed Oliver | DT | Mon, Sep 26 | Ankle | Questionable for Week 4 at Baltimore | - |
| Christian Benford | CB | Mon, Sep 26 | Hand | Out for Week 4 at Baltimore. | Week 8 |
Sunday, September 25, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Stefon Diggs | WR | Sun, Sep 25 | Lower Body | Questionable for Week 4 at Baltimore |
| Jake Kumerow | WR | Sun, Sep 25 | Ankle | Questionable for Week 4 at Baltimore |
| Spencer Brown | OT | Sun, Sep 25 | Illness | Questionable for Week 4 at Baltimore |
Saturday, September 24, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Micah Hyde | SS | Sat, Sep 24 | Neck | IR. Injured Reserve |
Friday, September 2, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Ike Boettger | OG | Fri, Sep 2 | Achilles | Physically Unable to Perform. | Week 5 |
Thursday, September 1, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Marquez Stevenson | WR | Thu, Sep 1 | Foot | IR. Injured Reserve. | Week 5 |
Tuesday, August 30, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Tre'Davious White | CB | Tue, Aug 30 | Knee - ACL | Physically Unable to Perform. | Week 5 |
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