Buffalo Bills vs Indianapolis Colts vs Tampa Bay Buccaneers defense: Week 6 fantasy projections and picks

Determining which defense to use in fantasy football lineups each week is based on several different factors. Which offense they are matched up against, as well as their recent performances, are often among the most important variables to consider. Here's the best streaming option in Week 6 between the Tampa Bay Buccaneers, Indianapolis Colts, and Buffalo Bills.

Buffalo Bills defense fantasy outlook for Week 6

Bills defense

The Buffalo Bills' defense has been inconsistent this year, running among the top six weekly units in two of their games but outside of the top 15 in their other three games. Their face-off against Aaron Rodgers and the New York Jets this week is a more favorable matchup than it may seem at first. He has been sacked 13 times this year and threw three interceptions last week.

Indianapolis Colts defense fantasy outlook for Week 6

Colts defense

The Indianapolis Colts' defense has struggled during the 2024 season, recording just one weekly finish better than the DST12 so far. The benefit of using them in Week 6 lineups is that they have an extremely favorable matchup against the Tennessee Titans, one of the worst offenses in the NFL.

Will Levis should give them scoring opportunities as he has already been sacked 15 times and thrown six interceptions.

Tampa Bay Buccaneers defense fantasy outlook for Week 6

Buccaneers defense

The Tampa Bay Buccaneers have been using their signature blitzing defense in 2024 to rack up 10 sacks across their past two games. They have also forced six turnovers this year, so they have been opportunistic. This makes them an intriguing defense to stream in Week 6 against the New Orleans Saints with Spencer Rattler making the first start of his career at quarterback.

Bills, Colts or Buccaneers defense: Who should I start in Week 6 fantasy football?

Who Should I Start

The Indianapolis Colts are the preferred streaming defense in Week 6 instead of the Tampa Bay Buccaneers and Buffalo Bills. All three units are projected to have similar fantasy scores this week, but the Colts get the edge by just fractions of a point, according to Sportskeeda's Who Should I Start tool.

This prediction demonstrates just how important weekly matchups are when it comes to choosing a streaming defense. While the Colts have been the weakest unit of the three options this year so far, they also have the best overall matchup this week. Levis is averaging more than an interception and three sacks per game, so the Colts should have plenty of scoring opportunities.